学术报告

报告题目：Antiviral RNAi in plants and mammals

报告地点：昆明市北京路2238号云南省农业科学院行政楼2楼1会议室

报告时间：2018年7月4日星期三上午 9:30

报告人：Dr. Shouwei Ding

Professor of Molecular Virology and Immunology,University of California, Riverside

Fellow of American Association for the Advancement of Science, Fellow of American Academy of Microbiology

邀请人：张仲凯研究员，云岭学者云南省农业科学院生物技术与种质资源研究所

丁守伟博士，美国加州大学河滨分校终身教授，美国科学促进会会士，国际著名植物病理学家、分子病毒学家，主要从事宿主RNA干扰（RNAi）抗病毒机制和病毒的反防御机制研究。在Science、Nature、Cell等顶尖科学杂志发表多篇重要影响力科研论文。

Key publications:

2017.Lipid flippases promote antiviral silencing and the biogenesis of viral and host siRNAs in Arabidopsis. ProcNatlAcadSci USA.114:1377-1382.

2017.Viral effector protein manipulates host hormone signaling to attract insect vectors. Cell Res27(3):402-415

2016. Induction and suppression of antiviral RNA interference by influenza A virus in mammalian cells. Nature Microbiol2:16250.

2014.Virus infection triggers widespread silencing of host genes by a distinct class of endogenous siRNAs in Arabidopsis.ProcNatlAcadSciUSA111(40):14613-8

2013. RNA interference functions as an antiviral immunity mechanism in mammals. Science 342:231-234.

2012. Homology-independent discovery of replicating pathogenic circular RNAs by deep sequencing and a new computational algorithm. ProcNatlAcadSci USA 109:3938-3943.

2011. The 21-nucleotide, but not 22-nucleotide, viral secondary small interfering RNAs direct potent antiviral defense by two cooperative Argonautes in Arabidopsis thaliana. Plant Cell 23:1625-38.

2010.RNAi-mediated viral immunity requires amplification of virus-derived siRNAs in Arabidopsis thaliana. ProcNatlAcadSci USA.107,484-489.

2010. Virus discovery by deep sequencing and assembly of virus-derived small silencing RNAs.ProcNatlAcadSci USA.107,1606-1611.

2010.RNA-based viral immunity. Nature Rev Immunol10:632-44.

2009.An RIG-I-like RNA helicase mediates antiviral RNAi downstream of viral siRNA biogenesis in Caenorhabditiselegans. PLoS Pathogens5(2): e1000286

2008. Mechanism of induction and suppression of antiviral immunity directed by virus-derived small RNAs in Drosophila. C ell Host & Microbe4:387-397.

2007.Antiviral immunity directed by small RNAs. Cell 130:413-426.

2006.RNA interference directs innate immunity against viruses in adult Drosophila. Science 312:452-454.

2005.Animal virus replication and RNAi-mediated antiviralin Caenorhabditiselegans. Nature 436:1040-1043.

2004. Three distinct suppressors of RNA silencing encoded by a 20-kb viral RNA genome. ProcNatlAcadSci USA101:15742-15747.

2004.Interferon antagonist proteins of influenza and vaccinia viruses are suppressors of RNA silencing.ProcNatlAcadSci USA101:1350-1355.

2002. Induction and suppression of RNA silencing by an animal virus. Science 296,1319-1321

欢迎广大科研人员和研究生光临！